Other medication

Hi 
I've just started on cds and currently still in starting protocol. I am trying to increase to 1/2 drop P hour but when I did found I got quite brain foggy and tired so I've gone back to 1/4 drop P hour. And still a bit more vague than usual on day 3. Is this common? How long should I persist with starting protocol before any benefit. Treating bout of covid with ongoing infections and general CFS as well as IBS and pain if possible. Also and most importantly can I take this with my medication which is Buprenorphine injections and antidepressants?
ThanksKim